Non-canonical Base Pair Database | Individual Record Page 411

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Department of Biology and Biochemistry | University of Houston

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NON-CANONICAL BASE PAIR DATABASE : Individual Record Page 411

Authors: Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA

Citation: Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition Particle Science 287(5456):1232-1239 February 18, 2000  [PDB link]

Base Pair Type: AC reverse Hoogsteen

Base Pair Category: Normal Purine-Pyrimidine Base Pairs; Trans Watson-Crick/Hoogsteen

Sequence Context: 5'  3'
C-A,Carbonyl-amino
A-C
G-G,Carbonyl-amino
3'  5'

Structure: Ribonucleoprotein core of the SRP

Pucker Info: C2' endo

Melting Point: *

Free Energy: *

Chemical Shift: *

Glycosidic Conf: *

Extra Info: A47 and C62 are universally conserved. The base pair is extruded into the minor groove and provides cross strand stacking between G61 and C46. Ser O-gamma of the protein forms base specific hydrogen bond with O2 of C62 and N6 of G8. Ala-377 O and N6 of G48 and Asn-380 and N2 of A47 also make base specific hydrogen bonds.

Figure: AC reverse Hoogsteen