Non-canonical Base Pair Database | Individual Record Page 425

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NON-CANONICAL BASE PAIR DATABASE : Individual Record Page 425

Authors: Agalarov SC, Sridhar Prasad G, Funke PM, Stout CD, Williamson JR

Citation: Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain Science 288:107-112 April 07, 2000

Base Pair Type: GA N7-N1,amino carbonyl

Base Pair Category: Flipped Purine-Purine Mismatches; Cis Watson-Crick/Hoogsteen

Sequence Context: 5'  3'
U G,*
G-A
G G,*
3'  5'

Structure: 16S rRNA of T. thermophilus, Tth T4 RNA, helices 22 & 23a

Pucker Info: *

Melting Point: *

Free Energy: *

Chemical Shift: *

Glycosidic Conf: *

Extra Info: A665 flips out of helix 22 and is inserted into helix 23a, it base pairs with G724 of helix 23a and stacks within helix 23a. This interhelical base-pairing fixes the orientation of helix 23a with respect to helix 22, thereby stabilizing the global conformation of the nearby upper three-helix junction (22, 23a, and 23b).

Figure: GA N7-N1,amino carbonyl