RNA World Informatics Phylogeny Database

NON-CANONICAL BASE PAIR DATABASE : Individual Record Page 8

Authors:	Durant PC, Davis DR
Citation:	Stabilization of the anticodon stem-loop of tRNALys,3 by an A+-C base-pair and by pseudouridine. Journal of Molecular Biology 285(1):115-31 January 08, 1999  [PDB link]
Base Pair Type:	AC wobble
Base Pair Category:	Normal Purine-Pyrimidine Base Pairs; Cis Watson-Crick/Watson-Crick
Sequence Context:	5'  3' A U,* A-C U-A,Watson-Crick 3'  5'
Structure:	Anticodon loop of tRNA (Lys)
Pucker Info:	A-U pair above has significant C2'-endo character
Melting Point:	50.6 [pH=7.2]; 56.8 [pH=5.0]
Free Energy:	1.8 [pH=7.2]; 3.0 [pH = 5.0]
Chemical Shift:	*
Glycosidic Conf:	*
Extra Info:	Protonation at N1 site of A which acts as a hydrogen bond donor in AC Wobble pair, the pKa of this proton is shifted to a higher value (~6.0)
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